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DEUSDEDIT TUSUBIRA

Title: 
Dr
Institution: 
Designation: 
LECTURER/ ACTIND HEAD OF DEPARTMENT

Name:      Dr. Deusdedit Tusubira

Position:  Lecturer; Acting Head of Biochemistry Department

Qualifications:  Bsc.( Mak),  Msc.( Liverpool),  PhD ( Bergen)

Email address: dtusubira@must.ac.ug

Research group or field you are active: Mitochondrial metabolism, diseases across a lifespan, Diagnostics in the developing world

Role: co-investigator

Research interests

  1. Biomedicine
  2. Molecular biology of parasites and disease vectors with particular interest in molecular mechanisms of resistance to agents used in control
  3. Diseases across a lifespan including embryonic programming especially the role of energy availability on later life diseases
  4. The nexus that links metabolic rewiring with its associated pathophysiology and its implications for healthy aging and longevity
  5. Diagnostics including molecular targets for incorporation in low cost point of care devices.

Unique responsibilities in the Department (if applicable)

  • Coordinator postgraduate studies biochemistry

Any notable achievements

  • Head of Department from 2019 up to date

Role related posts held:

  • Member of the Faculty Research Committee.
  • Member of the Faculty postgraduate Committee

Projects

Diagnostics and the developing world

https://mbdiagnostics.wordpress.com/people/   https://ddwconference.com/information/

A star science clubs for promotion of science to young people

https://biochemicalsociety.wordpress.com/2012/10/03/a-science-club-launch/

Publications 

https://scholar.google.com/citations?user=OLtPhEcAAAAJ&hl=en&oi=ao

 https://orcid.org/0000-0002-4698-424X  

1. Røsland, G.V., Dyrstad, S.E., Tusubira, D., Helwa, R., Tan, T.Z., Lotsberg, M.L., Pettersen, I.K., Berg, A., Kindt, C., Hoel, F. and Jacobsen, K., 2019. Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC. Cancer & metabolism7(1), pp.1-18.

https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-019-0197-8

2. Dyrstad, S.E., Tusubira, D., Knappskog, S., Tronstad, K.J. and Røsland, G.V., 2018. Introducing nano-scale quantitative polymerase chain reaction. Biochemical and biophysical research communications506(4), pp.923-926.  https://www.sciencedirect.com/science/article/pii/S0006291X18322733

3. Pettersen, I.K.N., Tusubira, D., Ashrafi, H., Dyrstad, S.E., Hansen, L., Liu, X.Z., Nilsson, L.I.H., Løvsletten, N.G., Berge, K., Wergedahl, H. and Bjørndal, B., 2019. Upregulated PDK4 expression is a sensitive marker of increased fatty acid oxidation. Mitochondrion49, pp.97-110.

https://www.sciencedirect.com/science/article/pii/S1567724919300856

4. Tusubira, D., 2019. A study on features and markers of cellular metabolic rewiring. https://bora.uib.no/bora-xmlui/handle/1956/19245

5. Lindquist, C., Bjørndal, B., Rossmann, C.R., Tusubira, D., Svardal, A., Røsland, G.V., Tronstad, K.J., Hallström, S. and Berge, R.K., 2017. Increased hepatic mitochondrial FA oxidation reduces plasma and liver TG levels and is associated with regulation of UCPs and APOC-III in rats. Journal of lipid research58(7), pp.1362-1373.

https://www.sciencedirect.com/science/article/pii/S0022227520335872

6. Tuyiringire, N., Tusubira, D., Munyampundu, J.P., Tolo, C.U., Muvunyi, C.M. and Ogwang, P.E., 2018. Application of metabolomics to drug discovery and understanding the mechanisms of action of medicinal plants with anti-tuberculosis activity. Clinical and translational medicine7(1), pp.1-12.

https://clintransmed.springeropen.com/articles/10.1186/s40169-018-0208-3

7. Dyrstad, S.E., Lotsberg, M.L., Tan, T.Z., Pettersen, I.K.N., Hjellbrekke, S., Tusubira, D., Engelsen, A.S.T., Daubon, T., Mourier, A., Thiery, J.P. and Dahl, O., 2020. Inhibition of pyruvate dehydrogenase kinase redirects NSCLC cell metabolism and counteracts development of resistance to epidermal growth factor receptor tyrosine kinase inhibitors.

 https://www.researchsquare.com/article/rs-29590/latest.pdf

8. Dyrstad, S.E., Lotsberg, M.L., Tan, T.Z., Pettersen, I.K., Hjellbrekke, S., Tusubira, D., Engelsen, A.S., Daubon, T., Mourier, A., Thiery, J.P. and Dahl, O., 2021. Blocking Aerobic Glycolysis by Targeting Pyruvate Dehydrogenase Kinase in Combination with EGFR TKI and Ionizing Radiation Increases Therapeutic Effect in Non-Small Cell Lung Cancer Cells. Cancers13(5), p.941.

https://www.mdpi.com/1009622

9. Tuyiringire, N., Deyno, S., Weisheit, A., Tolo, C.U., Tusubira, D., Munyampundu, J.P., Ogwang, P.E., Muvunyi, C.M. and Vander Heyden, Y., 2020. Three promising antimycobacterial medicinal plants reviewed as potential sources of drug hit candidates against multidrug-resistant tuberculosis. Tuberculosis, p.101987.  https://www.sciencedirect.com/science/article/pii/S1472979220301542

10.  Tusubira D. The biomedical sciences in Uganda: a review 

https://www.academia.edu/4388275/Biomedical_science_in_Uganda

 

 

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